I’ve stayed away from wxPython in the past because updates were slow and Python 3 wasn’t supported. Within the last couple of weeks, 4.0 was completed, which at least answers the Python 3 problem. I’ve been pounding my head against X11 idiosyncracies all weekend, so I thought I’d take a break and try it out.
Dependencies It looks like the prequisites were sourced from Debian.
$ sudo dnf install -y {dpkg,freeglut,gstreamer{,1}-plugins-ba{se,d-free},gtk3,lib{jpeg,notify,SM,tiff},python{2,3},SDL}{,-devel} @development-tools
